The Explanation of Osteoporosis by the Autoimmunity Theory

As we all noticed osteoporosis is connected very tightly with the estrogen level and the estrogen receptor. That is why it occurs after the menopause period by women and is more common by ovariectomized patients.

In my book “The Theory of Autoimmunity” I already explained the main principles of the pathophysiology of most common diseases. As an example for explaining osteoporosis I would use the most common to it disease such as diabetes type 2.

Many diseases affect not only humans but also some animal species. This leads to the conclusion that there are similar proteins on the cell membranes and in the cytoplasm in humans and animals. Digesting similar to our proteins may lead to an autoimmune reaction against our proteins and degeneration of some tissues like blood endothelium, respiratory endothelium cells, pancreas Langerhans cells, the cells of the nephrons, or even the death or destruction of brain cells, causing great number of diseases.

An Example for the autoimmune theory is Diabetes Mellitus Type 1

Diabetes mellitus type 1 has long been known medical disease. But lethality of diabetes begins only when people begin to therapy it. Why?

It has long been known that diabetes type 1 is caused by an immune response to beta cells of the islets of Langerhans (of the same which go on vacation).

1. It is known that the immune system responds only to proteins, i.e., Why not to the protein of insulin?

2. It is known that porcine insulin differs by only 2 amino acids from human. I.e. why not exogenously induced immune response (e.g. alimentarian autoimmune reaction)? The porcine insulin in the food gets into the gastro-intestinal tract, thence through erosions of the gastrointestinal tract gets into the lymphatic system, where antibodies against it are built. These antibodies react against porcine insulin and against human insulin (because they are common in structure). Thus they destroy the beta-cells of the islets of Langerhans by an immune reaction type B. It leads to the conclusion that Type 1 diabetes is caused by autoimmunity against insulin.

In conclusion: bovine and porcine insulin are too common with human insulin. They are foreign protein molecules and cause immune reaction, the antibodies built against them react also to human insulin and cause the destruction of Beta-cells in pancreas, inducing diabetes type I.

Another example of the logic of autoimmune theory is Diabetes mellitus Type II

Bovine and porcine receptors to insulin are also common with human receptors. Consuming big amounts of them, found in the muscle tissue of animals, causes the production of human antibodies against them. These antibodies connect themselves with human insulin receptors in human organism. That causes insulin resistance in human tissues. On back-forth connection mechanism this causes increasing of insulin levels in blood. This causes constant hunger and increasing of food consumption, thus obesity and metabolic syndrome. In this vicious circle soon the capacity of human Langerhans cells to produce insulin is exhausted and this leads to diabetes type II.

Obesity is often associated with the development of insulin resistance. According to the popular way to overcome insulin resistance, those affected should consume meat and meat products and avoid carbohydrates that are rich in plants. However, this is completely wrong. According to autoimmune theory, insulin resistance and obesity are caused by eating meat with the food. Through food in meat in the GIT enter a lot of animal insulin receptors (because muscle tissue is rich with them) they pass through the intestinal wall into the interstitium and in the lymph stream. These foreign proteins elicit an immune response and the production of antibodies that mistakenly respond to the human insulin receptors, causing insulin resistance and subsequent obesity and diabetes type 2. Therefore, the most appropriate treatment for obesity and diabetes is the exclusion of animal products of food.