Skip to main content

CoViD-19 and ACE inhibitors

 


The disease is often moderate or even asymptomatic. However, severe courses can occur, usually manifesting as pneumonia. In some of the seriously ill patients, severe cardiovascular damage is also observed.

For people with heart disease, the disease - which is caused by the SARS-CoV-2 virus - thus appears to be particularly dangerous.

Angiotensin-converting enzyme 2 (ACE2) plays a major role in the body's water balance. ACE inhibitors lower blood pressure and reduce afterload - which also makes them very useful in treating heart failure disease.

ACE2 are particularly abundant in the heart and lungs. Currently, attention is focused on this enzyme because ACE2 has been identified as a functional receptor for the coronaviruses SARS-CoV and SARS-CoV-2.

It appears that the amount of ACE2 increases by taking ACE2 inhibitors in response. Thus, the body responds to inhibition of these receptors by increasing potential docking sites.

It has not yet been proven whether this mechanism promotes or exacerbates the disease!

Up-regulating ACE2 may also have benefits: The enzyme protects the heart and vasculature by cleaving angiotensin II-which promotes hypertension, edema, and tissue damage-and thereby inactivating it.

In SARS-CoV infection, ACE2 is downregulated as an antiviral protective measure: Angiotensin II can then promote severe tissue damage during infection. ACE inhibitors and sartans could therefore be helpful because they slow down angiotensin II formation or block the corresponding receptor, respectively ...

It is a fact that special attention is paid to patients with underlying cardiovascular disease in connection with covid-19 disease. Recently, experts from the U.S. Cardiac Society (ACC) considered the viral epidemic from a cardiology perspective in an official letter of recommendation. The society makes nine recommendations for managing the coronavirus epidemic.

The experts recommend that "consistent use of guideline-based therapy with plaque-stabilizing agents (statins, beta blockers, ACE inhibitors, ASS) provides additional protection for cardiac patients, and such treatment should be tailored to individual patients." Accordingly, these experts do not currently consider ACE inhibitors to be critical.

That this is a preliminary assessment is reflected in point 9 of the recommendation: here, the experts point out that little is currently known about coronavirus and physicians should be prepared for new recommendations as more information becomes available.

Source: www.pharmazeutische-zeitung.de/



https://www.amazon.com/Immunization-Against-Covid-19-Causes-Autoimmunity-ebook/dp/B0C57FTC7Z/ref=sr_1_2?crid=1WNZ8IOY2PJRU&dib=eyJ2IjoiMSJ9.5wrdOsjvqcIlR1eWM7BwvpKGZScR--CupFVOtDU1VrYkt6LDQvP2GhtI5xSDACqvIKmE-4SiRnM9x2-RGhMXXVgaoIpZHBLPqVwnJzIGWP8.l0Lk74hevPc9aifuYIeS35Ayksizu0BCNtk7js9sRlg&dib_tag=se&keywords=tanya+guleria+theory+of+autoimmunity&qid=1730545376&sprefix=%2Caps%2C186&sr=8-2

Comments

Post a Comment

Popular posts from this blog

Periprothetische Infektionen: aktueller Stand der Diagnostik und Therapie

N. Renz, A. Trampuz Biofilm-assoziierte Infektionen von Gelenkendoprothesen sind ein herausforderndes und komplexes Krankheitsbild und bedürfen des interdisziplinären Managements von erfahrenen Infektiologen, Mikrobiologen, Orthopäden und Unfallchirurgen. Mit einem optimalen Therapiekonzept werden bei periprothetischen Infektionen Behandlungserfolgsraten von über 90 % erreicht. Infektionen von Gelenkprothesen © Julianemartens/Fotolia 20 Orthopädie & Rheuma 2015; Die Infektionsrate nach Implantation einer Gelenkendoprothese reicht von rund 1% bei Hüft- und Schulterprothesen bis hin zu 2–3% bei Knie-, Sprunggelenk- und Ellbogenprothesen. Die wahre Inzidenz liegt wahrscheinlich aufgrund von nicht erkannten Low-Grade-Infektionen deutlich höher [1]. Bei Wechseloperationen steigt das Risiko einer Infektion auf bis zu 15% [2, 3]. Innerhalb der ersten zwei Jahre nach der Primärimplantation wird das Infektionsrisiko auf 0,5% pro Jahr geschätzt, im weiteren Verlauf beträgt die Infektio...
2 comments
Read more

In Search of The Perfect Sleep Aid

 For many years, modern medicine has been searching for the perfect sleeping pills. Sleeping pills are a special topic in medicine because they have a lot to do with addiction medicine. Of course, not every sleeping pill can cause addiction, but lighter sleeping pills such as valerian tablets, doxylamine succinate (contained in Schlafsterne), melatonin (or Circadin) have short and insufficient effects. Benzodiazepines, on the other hand, relieve anxiety, which often leads to sleep disorders and are often used by GPs as sleeping pills, although this is not correct. Antidepressants such as mirtazapine are more often used as sleeping pills, but patients often complain of fatigue and drowsiness after their use, which is incompatible with driving, for example. Z-drugs are the 3rd choice of sleep medicine, they have a long and sufficient effect, but can be very addictive. There are patients who struggle for years with addiction to zolpidem, or zopiclone. Many GPs give up in this fight an...
Post a Comment
Read more

Психически тормоз на работното място

Идеята за тази статия се зароди след посещението ми на Балинт група, която е част от специализацията ми за личен лекар в Германия. Неприятно ми е да го призная, но много чуждестранни колеги са подложени на псичически тормоз от страна на по-висшестоящи в йерархията лекари от немски проижод, или лекари, които също са с чуждестранен произход, но са израстнали в Германия и владеят езика по-добре от лекарите, които са жертви на псичически тормоз. Всеки знае, че много лекари пристигат в Германия, за да упражняват професията си заради по-доброто заплащане и условия на живот. Много лекари пристигат от страни, в които се водят военни конфликти. Забелязала съм, че много висшестоящи немски лекари имат така да се каже надменно и неуважително отношение към такива колеги. В Балинт групата бе представен случай от чуждесатранен колега, след което той бе представен от наша колежка, която очевидно владееше немски език по-добре от него като мързелив и некомпетентен, въпреки че случаят бе еднозначен и гов...
Post a Comment
Read more